Human GM-CSF is a monomeric glycoprotein that acts like a cytokine . Released from cells, such as macrophages, mast cells, T cells, endothelial cells, fibroblasts, and natural killer cells, it can act in a paracrine fashion to recruit circulating monocytes, lymphocytes and neutrophils for host defense mechanisms. Unlike colony-stimulating factor 3 that specializes in the proliferation and maturation of neutrophils, GM-CSF stimulates a spectrum of cell types especially eosinophils and macrophages.
Human GM CSF is a monomeric glycoprotein that acts as a cytokine in humans. Though secreted locally, GM-CSF stimulates the proliferation and maturation of several types of blood cells. Macrophages, mast cells, T cells, endothelial cells, fibroblasts, and natural killer cells are some of the cell types that secrete human GM-CSF. These cells release human GM-CSF as a reaction to signals from neighboring cells.
Human GM-CSF is a monomeric glycoprotein that acts as a cytokine with immunomodulatory functions. It is secreted by macrophages, mast cells, T cells, endothelial cells, fibroblasts, and natural killer cells. GM-CSF has been shown to be beneficial in the treatment of inflammatory conditions such as dermal and articular rheumatism, degenerative disorder of the joint or osteoarthritis. GM-CSF also stimulates the proliferation of hemopoietic stem cells during bone marrow transplant and prevents graft-versus-host disease.
Cancer and Leukemia patients may need Human GM-CSF because it stimulates the growth and maturation of eosinophils and macrophages. Eosinophils are white blood cells that help protect against certain parasites and play a major role in fighting off infections. Macrophages are white blood cells that contain granules of toxic chemicals that kill bacteria, fungi, and cancer cells. Patients with leukemia or lymphoma may also have low levels of GM-CSF due to chemotherapy or radiation treatments.
Interferon-gamma or IFN γ or is a human dimerized soluble protein encoded by the IFNG gene. The biologically active IFN γ is an interlocking anti-parallel form of two monomers. IFN γ is the sole member of the type II IFN group. IFN γ binds to the IFN-γ receptor complex to elicit a cellular signal. Two subunits, IFNGR1 and IFNGR2, make up the IFN-γ receptor complex.
Interferon-gamma or IFN γ is a protein encoded by the human gene IFNG. The biologically active IFN γ is an interlocking anti-parallel form of two monomers. IFN γ binds to the IFN-γ receptor complex to elicit a cellular signal. Two subunits, IFNGR1 and IFNGR2, make up the IFN-γ receptor complex. Interferon-gamma or IFN γ is a dimerized soluble protein encoded by the IFNG gene. Two subunits, IFNGR1 and IFNGR2, make up the interferon-gamma receptor complex. Interferon-gamma plays a crucial role in innate and adaptive immunity. It fights against viral replication, inhibits bacteria, and modulates and stimulates the immune system.
Interferon-gamma or IFN γ is a protein encoded by the IFNγ gene and is also known as immune interferon, fibroblast interferon, or leukocyte interferon. It is one of the most studied proteins due to its role in the body’s immune system and its connection to many diseases. IFN γ is a mouse interferon gamma elisa that plays a crucial role in innate and adaptive immunity.